Multiple sclerosis is a form of demyelinating disease. It is the disease of the nervous system in which the neuron's myelin sheath, a lipid-rich substance is damaged. The myelin is responsible for insulating axons to ensure the rapid flow of information from one nerve cell to another. This damage causes an inability in the parts of the nervous system to communicate. The signs and symptoms of the disease include mental, physical and psychiatric problems. Multiple sclerosis is the most common immune-mediated disorder that affects the central nervous system. The symptoms are determined by the locations of the lesions in the nervous system. This includes changes in sensation such as tingling, pins or numbness, muscle weakness and spasms, blurred vision or difficulty in moving. The person diagnosed with multiple sclerosis also experiences difficulties in coordination and balance, problems with speech or swallowing and chronic pain. This book includes some of the vital pieces of work being conducted across the world, on various topics related to multiple sclerosis. It consists of contributions made by international experts. It will provide comprehensive knowledge to the readers.